Annals of Oncology: Official Journal of the European Society by Brian L. Samuels, John E. Ultmann (auth.), John E. Ultmann,

By Brian L. Samuels, John E. Ultmann (auth.), John E. Ultmann, Brian L. Samuels (eds.)

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Extra resources for Annals of Oncology: Official Journal of the European Society for Medical Oncology

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We proposed that HRS cells represent neoplastic counterparts to activated T or B cells [7]. However, the observation that the Epstein-Barr virus (EBV) can induce the expression of CD30 and CDw70 in peripheral T cells and B cells [7] suggests that the expression of CD30 and CDw70 molecules by HRS cells may also be interpreted differently; their expression may also be a result of EBV infection of HRS cells. Following these lines of thought, we investigated extracted DNA of 42 cases of HD for the presence of EBV genomes using the Southern blot technique.

20. Stein H, Gerdes J, Schwab U, Lemke H, Diehl V, Mason DY, Bartels H, Ziegler A. Evidence for the detection of the normal counterpart of Hodgkin's and Sternberg-Reed cells. Haematol Oncol1983; 1:21-29. 21. Weiss LM, Strickler JG, Warnke RA, Purtilo DT, Sklar J. Epstein-Barr viral DNA in tissues of Hodgkin's disease. Am J Pathol1987; 129:86. 22. Anagnostopoulos I, Herbst H, Niedobitek G, Stein H. Demonstration of monoclonal EBV genomes in Hodgkin's disease and Ki-1 positive large cell anaplastic lymphoma by Southern Blot and in situ Hybridization.

7. Richards MA, Webb JAW, Jewell SE et al. Low field strength magnetic resonance imaging of bone marrow in patients with lymphoma. Br J Cancer 1988; 57: 412-415. 8. Smith SR, Williams CE, Davies JM et al. Bone marrow disorders: Characterisation with quantitative MR imaging. Radiology 1989; 172:805-810. 9. Jagannath S, Armitage JO, Dicke KA eta!. Prognostic factors for response and survival after high dose cyclophosphamide, carmustine and etoposide with autologous bone marrow transplantation for relapsed Hodgkin's disease.

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